A Next Generation Chromatographic Media Enabling the Fast, Reliable Purification of Monoclonal Antibodies

ZirChrom introduces a biocompatible stationary phase (Rhinophase®-AB) useful for small and large-scale purification of bio-molecules. Rhinophase®-AB may be packed into columns or SPE tubes and run at very high mobile phase linear velocities compared to the mechanically soft affinity gels such as Protein A and Protein G, which results in a dramatic increase in purification throughput. Furthermore, Rhinophase®-AB can effectively purify a wide range of Mab subclasses, as well as polyclonal hIgG, IgA and IgM, providing an almost universal antibody purification media. Rhinophase®-AB is available in 3, 5, 10 and 25 micron particle sizes.

  • Biocompatible
  • Non-Compressible
  • Unique Specificity
  • High Throughput
  • Ultra-Stable

Complete Solutions for Monoclonal Antibody Purification

ZirChrom now offers two complete solutions for monoclonal antibody purification: 1) the Rhinophase®-AB Research Kit (top right; part# AB01-RES) and 2) the Rhinophase®-AB Production Kit (bottom right; part# AB01-HTP).  Each kit contains the items necessary to perform laboratory scale purifications (just add water!).  The Research Kit is designed for small scale jobs. The Production Kit employs a vacuum filtration apparatus for high throughput applications (see below).


Note: Due to zirconia's very high mechanical strength, Mab purifications can be performed at high mobile phase linear velocities. A simple vacuum filtration apparatus included with the Rhinophase®-AB Production Kit (part# AB01-HTP) can be use to achieve very high flow rates through a packed bed (90 mL/min). This approach is not possible using soft affinity gels such as Protein A and Protein G media.

Rhinophase-AB Application Information

Rhinophase-AB Presentation Slides (PDF)

E-Newsletter Vol 6 - Rhinophase®-AB, Zirconia-based Mab Purification System, August 2003

Rhinophase-AB Research Kit  - Quick Start Guide

Rhinophase-AB Production Kit  - Quick Start Guide

Rhinophase-AB SDS (PDF)

To place an order, or for more information or copies of our Technical Application Notes, please contact us at 1-866-STABLE-1.


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